International Perspective | Healthy Sleep: ZJ1+PQQ
Sleep is an extremely important physiological function to maintain human life. According to a survey by the World Health Organization, 27% of people worldwide have varying degrees of sleeping problems. Researches from the University of Washington School of Medicine published their research in the journal Nature Metabolism, stating that NMN can directly enter the cell, increase the production of the neurotransmitter dopamine which improves the mood and the ability to withstand stress, reduce or even curb nicotine craving. The biological clock, which is responsible for the molecular mechanism of feedback loop is repaired. Normal circadian rhythm is restored and deep sleep increases.
ZJ1 NMN can improve quality of sleep, but what is the principle or mechanism behind it? In fact, this is due to the adjustment of the circadian clock by NAD+. BY taking ZJ1 NMN, it enters the body and is converted to NAD+. NAD+ wakes up SIRT1, which adjusts the biological clock. It can help sleep disorders greatly, particularly those caused by lifestyle factors and aging.
The dangers of biological clock disorder
The biological clock is an invisible “clock” in our bodies. It actually refers to the various physiological and biochemical activities in different organisms that change periodically with time. All animals on the planet have a physiological mechanism called the biological clock. The area of the human hypothalamic suprachiasmatic nucleus is above the upper oral palate. We have circadian rhythm for sleep, waking and eating behaviors because of our biological clock.
Scientific research also shows that the biological clock regulates human health. If people do not rest according to their biological clock, their productivity will be low and it may cause complex diseases such as obesity, diabetes, high blood pressure, depression and tumors. Sleep studies has shown that long-term insomnia can lead to lack of focus, memory loss, abnormal decision making, induces premature aging, hypertension, myocardial infarction, hyperlipidemia, obesity and even cancer. It can also cause anxiety, depression and even hallucinations.
How does taking ZJ1 NMN improve sleep?
ZJ NMN can improve sleep, in fact, it is still related to NAD+. The reason why NAD+ improves sleep is related to one of the longevity proteins SIRT1.
ZJ1 NMN is a direct precursor of NAD+. NAD+ is closely related to the biological clock.
Its interaction with the biological clock is manifested in the following ways: the metabolism of NAD+ is regulated by the biological clock, which in turn also affects the biological clock. It is SIRT1 that connects the enzyme feedback pathway of the NAD+ salvage pathway and the circadian rhythm transcription-translation feedback loop, forming a “NAD+-SIRT1-CLOCL:BMAL1-NAMPT-NAD+” loop. Therefore, interference with the biological clock affects NAD+ synthesis, and interference with NAD+ also has an effect on the biological clock.
Therefore, through the exogenous intake of the precursor of NAD+, that is, ZI1 NMN can regulate the disordered biological clock of people with sleep disorders and restore it to a normal circadian rhythm.
Since the NAD+ molecule is too large to be absorbed directly from the outside of the body, we can take ZJ1 NMN to convert it into NAD+ in the body, allowing NAD+ to start up SIRT1 and improve our sleep mechanism.
How ZJ1 NMN regulates the circadian rhythm of the elderly
Unlike the sleep disorder of young people, the sleep of the elderly is actually regular. However, their circadian rhythm is often unhealthy. Many elderlies have shortened sleep and wake up multiple times in the middle of the night. In fact, this is also symptoms of problems with the circadian rhythm. The reason is inseparable with the lack of NAD+. As the age increases, the NAD+ level of the oscillator and the main clock decreases, the SIRT1 level decreases, and the clock gene expression decreases, resulting in a longer natural cycle and poorer adaptability.
Supplementing with NAD+, which is supplementing with ZJ1 NMN, can adjust the natural cycle of the biological clock to make it more adaptable. The most direct result is that after taking ZJ1 NMN, many elderlies have improved sleep quality and are more likely to sleep till dawn.
ZJ1 NMN+PQQ obtained FDA certification, entered the united states Pharmacopeia and is recognized by more than 140 countries worldwide. It passed the raw material and product testing by highest standard FDA certified laboratory. The testing has shown that ZJ1 NMN+PQQ rank first in safety and effectiveness among similar products.
ZJ1 NMN+PQQ obtained FDA certification
The world leading FDA certified NMN+PQQ supplements
FDA, the Food and Drug Administration was established in 1906. It was authorized by the US Congress and it is the highest law enforcement agency specializing in food and drug administration. The FDA has a huge impact in the United States and the world. It is known as the “Guardian of American Health”. Its credibility and professional standards have become the shield for food and drug customers.
“ZJ1 high energy NMN+PQQ regulates cell function in two effective ways. It enhances cell activity and human longevity protein, comprehensively improve human immunity, delay ageing and extend human life. It is FDA certified and the first choice of NMN product in the world!”
“ZJ1 high energy NMN+PQQ dietary supplement: Good sleep, good anti-aging, good longevity, comprehensive immunity improvement, FDA certified, exclusive to Hong Kong Zhong Ji International Health Association. 2 capsules a day, helps maintain health and vitality, and is the first choice for daily anti-aging supplements.”