Nature: Clearing “Worn-out Cells” Extends Life By 30%
Cells undergo an aging phase before they stop dividing. During this time they neither die nor divide and multiply, but continue to create saboteurs, attacking and killing nearby healthy cells. The medical profession speculates that this property exists to prevent cell proliferation and cancer spread. The aging cells accumulate in the body, and if they cannot be cleaned up by the immune system in time, they will become “Worn-out cells", causing senescent diseases.
The self-stabilizing function of the human immune system can identify the elimination of senescent cells and dead cells in the body, which can delay aging and reduce the incidence of chronic diseases.
So, do immune cells delay aging, and do the effects have quantitative criteria?
Sure! The top international research journal has published a research report that has sparked global debate:
Mayo clinic experiments show that clearing “Worn-out cells" can extend life expectancy by 30%!
Clear “Worn-out cells" , could be extended life by 30% (researched by using rat)
Mayo Clinic molecular biologists Baker and Van Deursen report in that removing senescent cells (Worn-out cells) can extend the lifespan of these animals by 20–30%.
△ Baker and his teammates published their research result in
Compared to animals that have not cleared worn-out cells, these rats that have been cleared of worn-out cells can be young for 6 months, equivalent to humans to decade for Dozens years!
In some aspects, those worn-out cells that are cleared within 6 months inside the rat body are healthier than those that allow these cells to grow.
△ After treatment of aging rat with the anti-aging drug AP20187 (AP), the median survival days and survival rate of the rat increased significantly. Eliminate the accumulation of Worn-out cells in the body, the life of the rat is increased by about 30%
These animals have enhanced kidney function and the heart is more resistant to stress. They are more active in the cage and have a delayed cancer. It means that, it has an ideal anti-aging effect in terms of physical, mental and senescent diseases.
Although the immune system regularly removes worn-out cells, as the time goes by, the immune organs will continue to shrink, unable to produce enough new immune cells; and in the process, the types of immune cells will continue to decrease, leading to clearance. There are fewer and fewer types of heteromorphic cells.
However, worn-out cells produce a large amount of harmful substances such as cytokines, growth factors and proteases, thereby damaging nearby cells and stimulating local inflammation, causing various chronic diseases. Chronic diseases are closely related to weakness and age-related diseases.
Their team also found that eliminating worn-out cells can delay the onset of aging disease in rat. To find a cure for senescent disease, researchers are looking for drugs that can directly eliminate worn-out cells or prevent them from producing large amounts of damage to neighboring tissues. These include Baker and Van der Kelsen, who have applied for a patent for the development of such drugs to a company co-founded by Van der Kelsen.
Dr. Van Deursen believes that worn-out cells that accumulate with aging are very bad, can damage human organs and tissues, shorten life expectancy and healthy life. Given that these cells can be cleared in mice without side effects, it appears that drugs or other compounds that are capable of clearing worn-out cells may help treat age-related disability, disease or symptoms.
DominicWithers, a clinical scientist who studies aging at King's College London, said the findings led us to believe that worn-out cells are a viable way to treat disease. He published a journal in that echoes the Mayo scholar's research. It is believed that this study opens a window to anti-aging treatment.
Clearing “worn-out cells” is the most viable way to extend life
Clearing “worn-out cells” is the most viable way to extend life. A new study from the Mayo Clinic in the United States confirms that cell division is no longer possible, and that senescent cells that accumulate with age can be negative for health. The effect is to shorten the lifespan of normal rat by 35%.
These results also confirmed that clearance of senescent cells can delay tumor formation, maintain tissue and organ function, prolong life, and not observe any adverse effects.
△ Related research results published online in the journal of
To explore the physiological relevance and consequences of natural senescent cells, the researchers used a transgene that allowed the drug to induce the removal of senescent cells from normal rat. When a compound called AP20187 is administered, removal of senescent cells delays tumor formation and inhibits age-related degradation of multiple organs. The average lifespan of treated mice was extended by 17-35%. They also show a healthier appearance with reduced inflammation in fat, muscle and kidney tissues.
Eliminating worn-out cell anti-aging strategies in rat is a major turning point in the field of senescent cell research. This made the researchers very excited and able to remove the senescent cells from the animals without any danger, opening up a lot of new ideas for them: “One day, we may be able to break the link between the old and many diseases, thus find a revolutionary treatment for chronic diseases in the elderly. If you stop the aging process in the bud, do you also contain many age-related diseases? Cancer, Alzheimer's disease, arteriosclerosis, diabetes and their Can the complications be solved together?"
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